New research shows that in a mouse model of childhood absence epilepsy, brain activity is perturbed between seizures. The researchers speculate that this could underlie cognitive problems of the disease, which can persist despite treatment of seizures. That’s according to research published today in The Journal of Physiology.
Absence seizures cause a short period of “blanking out” or staring into space, due to brief abnormal electrical activity in the brain. In this new study, even after the seizures in the mice were treated, the abnormality that was previously seen between seizures persisted. This may provide a potential explanation for why some children with absence epilepsy may have Absence seizures , despite successful treatment of their seizures.
EEG, a test that measures electrical activity in the brain, has thus far been primarily used to detect seizures, rather than identifying cognitive impairment. This study suggests that looking at EEG activity between seizures could help physicians diagnose and monitor cognitive and other attentional deficits in epilepsy.
Source: Brain activity between seizures informs potential treatment for childhood absence epilepsy — ScienceDaily