Archives for category: research

New method uses biochemistry to accurately predict whether a child will develop autism spectrum disorder by measuring the products of metabolic processes.

Source: New biochemical method accurately diagnoses autism in children – Medical News Today


Researchers at Beth Israel Deaconess Medical Center (BIDMC) have gained new insight into the genetic and neuronal circuit mechanisms that may contribute to impaired sociability in some forms of Autism Spectrum Disorder. Led by Matthew P. Anderson, MD, PhD, Director of Neuropathology at BIDMC, the scientists determined how a gene linked to one common form of autism works in a specific population of brain cells to impair sociability. The research, published in the journal Nature, reveals the neurobiological control of sociability and could represent important first steps toward interventions for patients with autism.

Anderson and colleagues focused on the gene UBE3A, multiple copies of which causes a form of autism in humans (called isodicentric chromosome 15q).Conversely, the lack of this same gene in humans leads to a developmental disorder called Angelman’s syndrome, characterized by increased sociability. In previous work, Anderson’s team demonstrated that mice engineered with extra copies of the UBE3A gene show impaired sociability, as well as heightened repetitive self-grooming and reduced vocalizations with other mice.

Source: The genes and neural circuits behind autism’s impaired sociability – Medical News Today


Fragile X syndrome is the most common cause of autism. Even though the single gene that’s responsible for it was discovered in 1991, and the disease is detected by a simple blood test, there’s no treatment or cure.

A team of researchers led by Michigan State University, however, has provided a promising lead in battling this disease. In the current issue of Nature Communications, the scientists identified a single protein that appears to be the culprit in causing many behavioral symptoms as well as molecular and cellular abnormalities related to Fragile X.

“We began with 600-800 potential protein targets, searching for the equivalent of a needle in a haystack,” said Hongbing Wang, MSU physiologist and study co-author. “Our needle turned out to be ADCY1. When we compared levels of this protein in Fragile X mouse model to normal controls, we saw a 20-25 percent increase of ADCY1.”

Subsequent tests of the team’s prime-target protein on the Fragile X mouse model revealed four key results. First, by reducing the expression of ADCY1, the team eliminated many autism-like behaviors. Second, the protein’s increased expression caused increased signaling in neurons. By reducing levels of ADCY1, the team dampened neuron signaling to levels within a normal range.

 

Source: Researchers find promising lead that reduces autism symptoms and more – Medical News Today


Researchers have observed that a protein called SHANK prevents the spread of breast cancer cells to the surrounding tissue. The SHANK protein has been previously studied only in the central nervous system, and it is known that its absence or gene mutations are related to autism.

Source: Unexpected link between cancer and autism — ScienceDaily


The potential repeal of the Affordable Care Act (ACA) threatens to eliminate critical mental and behavioral health services for people living with autism and other disabilities.

Source: Researcher calls on the scientific community to defend individuals with disabilities — ScienceDaily


This research proves that the ideology of this Tory Government is wrong and all they wish to do is govern to benefit themselves and their millionaire elites and multinational companies at the expense of the poor and vulnerable.

They believe if they can be rid of as many people who require benefits to live on then there will be more for themselves and the elites whom they favour.

Politics and Insights

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Folk devils and moral panic. The UK establishment created a dominant scapegoating narrative of people needing social security support

Comparative research, conducted at an international level, has undermined the government claim that the UK welfare state encourages “widespread cultures of dependency” and presents unemployed people with “perverse incentives”. 

The study, which links welfare generosity and active labour market policies with increased employment commitment, was published in 2015. It has demonstrated that people are more likely to look for work if they live in a country where welfare provision is generous and relatively unconditional. Empirically, the research includes more recent data and data from a larger number of European countries than previous studies.

The research also compared employment motivation in specific sub-sections: ethnic minorities, people in poor health, the low skilled, the non-employed and women, across countries, and adds to previous studies, which concluded that comprehensive welfare provision is increasingly seen as a…

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Being overweight or obese early in pregnancy was associated with increased rates of cerebral palsy in children, according to a study in Swedish women.

Source: Being overweight in early pregnancy associated with increased rate of cerebral palsy — ScienceDaily


Although autism appears to be on the rise, there are still no reliable biomarkers. A new study looking at links with cerebrospinal fluid may change this.

Source: Cerebrospinal fluid: Potential biomarker for autism found – Medical News Today


Study shows strong evidence of a link between excess body fat and cancers of the colon, breast, pancreas and ovary among others Being overweight could increase the risk of a host of cancers, including those of the colon, breast, pancreas and ovary, researchers have warned following a wide review of more than 200 studies. According to previous figures from two leading charities, almost three quarters of people are expected to be overweight by 2035, with 700,000 new cases of obesity-related cancer expected over the next 20 years. The new study by an international team adds weight to the warning, revealing that there is currently strong evidence for a link between excess body fat and an increased risk of 11 cancers: colon, rectum, endometrium, breast, ovary, kidney, pancreas, gastric cardia, biliary tract system and certain cancers of the oesophagus and bone marrow. “I think now the public and physicians really need to pay attention to obesity with respect to cancer,” said Marc Gunter, a

Source: Increased risk of 11 types of cancer linked to being overweight, researchers warn | DisabledGo News and Blog


Laura June reports for The Outline: New research published last week in the journal Elementa suggests that rising temperatures on Earth will cause massive changes in the deepest parts of the ocean.…

Source: Rising Ocean Temperatures Could Set Off a Chain Reaction That Threatens Our Food Supply

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